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Free radicals and antioxidants in normal physiological functions and human disease

Preclinical research evaluates its effects on muscle, bone, and other tissues to study growth-factor signaling and structural development

In this study involving chronic excessive activation of NMDA receptors to determine whether it would trigger mitochondrial ETC malfunction and lipid peroxidation in the brain, a reduction in complexes I and III was identified, where lithium was unable to protect these transmembrane proteins in the frontal cortex, where higher oxidative stress and ATP reduction were observed [59]

J Clin Invest 2009;119:3189202.ArticlePubMedPMC 29

July 28, 2016

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