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The ABCDE rule applied to lip lesions Dermatologists use a simple checklist called the ABCDE rule to evaluate any pigmented skin lesion, including those on the lips

It typically relates to active digestion from eating too close to bedtime, anxiety or racing thoughts from hormonal changes, or residual GI discomfort that prevents relaxation

Older secretagogues such as GHRP-2 and GHRP-6 measurably raised these hormones as well

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A meaningful increase (20-40% above baseline) confirms the protocol is active