Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion
However, intervention trials have not been convincing, and several studies have demonstrated no beneficial effect of vitamin E on cardiovascular disease outcomes
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10.1002/(sici)1096-9861(20000529)421:2 3.3.co;2-b 48 RubelE
In Summary: Side Effects & Warnings Mild side-effects are fairly common (GI discomfort, taste issues, minor rash) but typically resolve
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