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That area is still developing, and findings vary across medications, populations, and study designs, so it is best treated as an emerging part of the picture rather than a settled explanation

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Mazziotti, G., Angeli, A., Bilezikian, J

For peripheral nerve analysis, a 5-mm-long piece of tail 15 mm distal from the tail base was collected from each sacrificed animal, fixed in 4% formaldehyde in phosphate buffer (pH 7.4), decalcinated, and impregnated with 1% osmium tetroxide for a few days

To test whether this result is transferrable from 2D fibroblast culture to 3D human skin models, we extracted RNA from EFT-412 skin tissues following two-week MB treatment at 0.1, 0.5 and 2.5 M concentrations