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SREBP-2 silencing significantly decreased the expression of HMGCR , SQLE , LXR , CYP7A1 , and PCSK9 genes, while increasing LDLR gene expression compared to nontransfected control cells (Fig

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When the tumor volumes reached approximately 100 mm 3 , twenty female BALB/c nude mice bearing 143B tumors were randomly assigned into four groups

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