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E66.01 Morbid obesity due to excess calories

The results of the ACHIEVE-1 study, which were presented at the ADA congress in Chicago and simultaneously published in the New England Journal of Medicine, showed that once-daily orforglipron achieved significant improvements in haemoglobin A1c a market for blood glucose control at all three doses tested compared to placebo at 40 weeks

[12] This is mechanistically different from delivering a systemic analog to the whole body

GLP-1 patches are in development as needle-free alternatives

Potassium loss can be significant

The experimental timeline is depicted in Figure 1A