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Questions around creatine on Mounjaro often focus on whether supplementation may help improve strength and physical function during calorie restriction

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gingivalis has also been shown to increase BBB permeability (Lei et al., 2023) and is able to form particularly problematic biofilms similar to other gram negative spirochete bacteria that can also provide shelter for yet other microbes (Bao et al., 2014

Oral administration should be done on an empty stomach, preferably first thing in the morning at least 30 minutes before eating

So why not just go with the highest dose off the bat