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At a glance Most common cause / nausea and vomiting from GLP-1 GI side effects reducing fluid intake and increasing fluid loss Incidence of nausea (semaglutide 2.4 mg) / approximately 44% of participants in the STEP-1 trial reported nausea Incidence of vomiting (semaglutide 2.4 mg) / approximately 24% in STEP-1, the primary driver of acute fluid loss Incidence of diarrhea (semaglutide 2.4 mg) / approximately 30% in STEP-1, contributing to electrolyte depletion First-line treatment / oral rehydration with electrolytes

[2] [4] Pernicious anaemia is a lifelong condition requiring indefinite treatment

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Peptides are usually delivered via subcutaneous injection, which is very similar to how insulin injections help those with diabetes

Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors