doi:10.1038/s41598-025-97143-8 Dawson SL, Bowe SJ, Crowe TC
But we dont just want to lose weight, we want to lose body fat
Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions
The sudden weight loss, then weight gain also wreaks havoc on your metabolism. Due to their similar functions in weight loss and diabetes management, Ozempic/Wegovy and Mounjaro/Zepbound are linked to similar side effects
In phase I reactions, CYP1A1/2 and CYP3A4 oxidise estrogen to a 2-hydroxylated catechol estrogen, whereas CYP1B1 (which is constitutively expressed in the breasts, ovaries, adrenal glands, and uterus, as well as in several other tissues 13,14 converts it to 4-hydroxylated catechol estrogen 15,16
The absence of erectile dysfunction as a reported adverse event in the extensive clinical trial program for semaglutide suggests that if there is an effect, it is likely not common or severe enough to have emerged as a safety signal
