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It acts on GLP-1, GIP, and glucagon receptors, which makes it more comprehensive in its approach compared to Semaglutide, which focuses only on GLP-1

This does not mean weight regain is inevitable or total, but it does reflect an important biological reality: GLP-1 medications work in part by suppressing appetite and slowing gastric emptying, and when the medication stops, those effects stop too

Patients with obesity-related complications frequently have stronger medical necessity documentation because weight loss may improve overall health outcomes