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The first evidence that excessive GH-levels are involved in the pathogenesis of diabetic microangiopathy came from observations in diabetic patients undergoing pituitary ablation, which resulted in improvement of diabetic retinopathy in some but not all patients [199]

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Additionally, as most pivotal trials have limited duration and selective inclusion criteria, long-term safety and durability of response in diverse patient populations remain incompletely understood

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This results in reduced food intake, delayed gastric emptying, and improved satiety