I was inspired about this topic from a recent conversation I heard on the Duncan Trussell Family Hour Podcast between Duncan and Ram Dev
WEHI, 32D (32Dcl3), WT, T315I-BcrAbl-transformed 32D, and TCCS cells were maintained in RPMI 1640 medium (Sigma) supplemented with 10% heat-inactivated FBS, 1% Streptomycin/Penicillin, 1 mM sodium pyruvate, and 10 mM HEPES
I was thin therefore, I assumed that I was healthy
What's changing in 2026: with the FDA approval of finerenone for heart failure with preserved and mildly reduced ejection fraction, the "pillars" concept is expanding into territory that previously had almost no disease-modifying options
IGF-1 LR3 combines the best of both approaches: an N-terminal extension of 13 arginine-rich residues for steric IGFBP hindrance, Arg3 substitution to definitively abolish BP3 and BP5 binding, and retention of the 70 IGF-1 residues to maintain IGF-1R recognition
Symptoms may depend on the age and genetic disposition of the individual, and also the length and severity of deficiency