for Wegovy, follow the specific guidance in the product labeling
The well-documented risks are dosing errors from improper titration, severe dehydration from unmanaged nausea and vomiting, hypoglycemia in patients with undiagnosed metabolic conditions, adverse reactions in patients with unscreened contraindications, and contamination or incorrect concentration in products obtained outside licensed channels
In 2004, a piperazine drug, TFMPP, became the first drug that had been emergency-scheduled to be denied permanent scheduling and revert to legal status
Less common but concerning issues include increased blood pressure, pigmentation irregularities, and changes in libido
Most side effects improve with dose adjustments or timing changes before a break becomes necessary
382,383 Daytime blue light therapy is sometimes added to chronotherapy to support daytime alertness and enhance melatonin function in the evening, and may improve measures of daytime functioning and sleep quality