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Both preclinical and clinical studies have demonstrated that GLP-1s modulate the gut microbiota composition by delaying gastric emptying and altering luminal glucose ( Firmicutes Lachnospiraceae and Clostridiales ), alongside an increase in Proteobacteria (e.g., Burkholderiales bacterium YL45 ) and Akkermansia muciniphila a species largely associated with high-fibre diets and mucosal barrier health (6971)

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The mass interest in GLP-1 drugs has led to a business boom for the two dominant pharmaceutical players in this space, Lilly and Novo Nordisk, which sold over $7.3 billion worth of its GLP-1 drugs in the first three months of the year