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Am J Epidemiol 175:348358

Semaglutide is not recommended for people with personal or family history of medullary thyroid cancer, type 1 diabetes, or severe kidney disease

In the STEP 1 trial, once-weekly 2.4mg semaglutide produced a mean 14.9% body-weight reduction over 68 weeks establishing GLP-1 agonism as a leading anti-obesity mechanism

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Bariatric surgery generally produces greater long-term weight loss, while medications may be appropriate for others depending on their goals and health status

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