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For patients with strong genetic predisposition to weight regain or metabolic dysfunction, long-term maintenance therapy reduces the health risks of weight cycling

Research found that a decreased network response to stimulation in both excitatory and inhibitory circuits of the sensory cortex of Nlgn4 knock-out animals as compared to wild-type controls, and a decreased excitation-inhibition ratio, suggesting that Nlgn4 is involved in the regulation of excitatory and inhibitory circuits and contributes to a balanced circuit response to stimulation (88).Another study reports, Nlgn4 knockout disrupts GABAergic synaptic transmission and oscillatory activity in the hippocampus and causes deficits in social interaction

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It restores GSH levels and reduces the expression of superoxide dismutase (SOD) as well as the mRNA levels of catalase (Amazzal et al., 2007)

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26%) and steatosis (31% vs