Japan: The MHLW governs drug approvals, with Exenatide approved in 2010 and others following
Although there are only limited animal experiments suggesting that GLP-1 may lead to the development of psychiatric AEs (11), and there is no definitive evidence regarding the causal relationship between the use of GLP-1 RAs in humans and the development of psychiatric AEs, the fact that psychiatric AEs have occurred after the use of GLP-1 RAs suggests that these reports warrant increased clinical attention, early detection, and intervention
The findings come as more than 2,400 lawsuits over severe gastrointestinal side effects of Ozempic, Mounjaro, and similar medications continue in multidistrict litigation before Judge Karen Marston in the Eastern District of Pennsylvania
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Inhibitors of dipeptidyl peptidase 4 as therapeutic agents for individuals with type 2 diabetes: a 25-year journey
Its plasma half-life was longer than GLP-1, reaching 100~120 min
