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[37] Disclaimer: This compounded medication is prepared under section 503A of the U.S

The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993

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Acute caffeine administration preferentially antagonizes A 1 receptors, whereas repeated exposure primarily inhibits A 2A receptor signaling, resulting in distinct adaptive mechanisms [12, 69, 70]

Iron and ferroptosis: a still ill-defined liaison