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This interaction facilitates the dephosphorylation of the intermembrane space protein AIFM1 by PGAM5, which in turn triggers the release and nuclear translocation of AIFM1, ultimately leading to large-scale DNA fragmentation [106]

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Another way in which autophagy negatively regulates TBK1 stability is through the autophagy protein ATG4B, which serves as an adaptor for the recruitment of TBK1 to gamma-aminobutyric acid receptor-associated protein (GABARAP) via its LIR motif