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165 A systematic review that included eight studies with a total of 1,140 subjects with mild cognitive impairment living in countries without mandatory folic acid fortification showed folic acid interventions, with or without other B vitamins, decreased homocysteine levels by an average of almost 32%

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[17] However, no large-scale, controlled trials have evaluated the efficacy or safety of ALA for pregnant patients, and thus there is insufficient evidence to consider it definitively safe

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