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Pharmaceutics 13, 680

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The prodrome, marking the initial clinical phase of a migraine, manifests through symptoms believed to result from hypothalamic activation, such as difficulty concentrating, fatigue, yawning, neck stiffness, feelings of depression, and irritability (20, 21)

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According to data from Grand View Research, the global peptide market was valued at $140.86 billion in 2025 and is projected to reach $294.58 billion by 2033