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In summary, androgens/AR signaling alleviates mitochondrial oxidative stress by regulating the expression levels of mitochondrial respiratory chain-related enzymes such as Cox1/2 and CytB, decreasing the levels of peroxisomes (e.g., H 2 O 2 and MDA), increasing the antioxidant levels (e.g., SOD2 and GPX1) and enhances OXPHOS capacity through regulating MPC

However, SOD and catalase activity decreased on day 14 in VC + VE reflecting the superoxide and H 2 O 2 scavenging activity of vitamin C and vitamin E [5, 33-34]

Beyond its antioxidant properties, glutathione has been promoted for skin whitening primarily through oral supplements and intravenous injections Mechanism for Skin Lightening Glutathione affects skin pigmentation through multiple pathways