tirzepatide versus semaglutide weight loss vs. Semaglutide: Which Drug Works Better? [May 2025 NEJM Study Explained] Tirzepatide vs Semaglutide for Weight

[Epub ahead of print])

Deo SV, Marsia S, McAllister DA, Elgudin Y, Sattar N, Pell JP

Stroh, Justin

They note that their study has several limitations, including its reliance on self-reported acetaminophen use, which may be subject to recall bias

Weight Loss Journey and Expectations Every weight loss journey is different, and if youre curious about how much weight you lose, the amount will depend on your starting weight, dose, and how your body responds to treatment

While Glu9 of GLP-1 formed strong and persistent hydrogen bond and van der Waals interactions with R190 2.60 , Y152 1.47 , and to a lesser extent, Y148 1.43 , the polar side chain of Gln3 in oxyntomodulin only formed weak and very transient hydrogen bonds with these residues, and van der Waals interactions only with Y148 1.43 (Movie S1, Supplementary Table 3)