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These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (common, affecting up to 1 in 10 people) Vomiting (common) Constipation (common) Abdominal pain and discomfort (common) These gastrointestinal effects create the conditions for dehydration , which subsequently causes urine to become concentrated and darker
GLP-1RAs may modulate inflammation by reducing circulating pro-inflammatory cytokines such as TNF- and IL-6, which promote proteolysis via the ubiquitin-proteasome pathway [9]
Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, et al
doi: 10.2337/db22-717-P
How long does tirzepatide-related cold sensitivity last
CMS did not specify a required 3-month or 6-month lifestyle trial
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