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Key Administration Guidelines Timing: At least 30 minutes before the first beverage, food, or other oral medications of the day (make sure it does not react with this GLP-1), take Rybelsus 4 ounces of plain water or less

While both medications cause GI symptoms like nausea and diarrhea, tirzepatide may trigger these more often

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The group at risk of endometrial hyperplasia are those women using a GLP-1 and also using TD oestrogen (which will be unaffected by the GLP-1 agonist) and an oral progestogen, as the absorption of the progestogen may be reduced while the oestrogen stays the same, leaving the woman with an unbalanced regime and an insufficient amount of progestogen to protect her endometrium from the oestrogen

For women with PCOS or obesity-related ovulatory dysfunction, these metabolic improvements could theoretically support better ovarian function

Patients will typically increase their dose once per month until they reach the effective dose