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33 Exposure in Chinese subjects was slightly higher than that observed in Caucasian and Japanese, however, after adjusting for differences in body weight, exposure in Chinese was similar to exposure seen in Caucasian and Japanese

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Given the established protective properties of both SGLT-2Is and GLP-1RAs on kidney function, this finding is unexpected if it truly represents the degree of fibrosis, suggesting that the observed changes in ADC may represent other changes in kidney microstructure