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494 Notably, in 2021, the United States FDA lifted the contraindication for statin use during pregnancy for high-risk patients, such as those with familial hypercholesterolemia, although routine use remains discouraged

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Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116

7b, c), consistent with the observations in our cell culture studies

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