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(Mackensen et al., 2001

This study identified ER as the major target for QIs-induced perturbations and a significant protective role of GSTP1 by alleviating loss of cell viability, enhancing detoxification of reactive QIs, and attenuating apoptosis

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Additionally, patients on medications that affect liver enzymes, particularly those that are substrates, inhibitors, or inducers of cytochrome P450 enzymes, should be monitored for changes in drug efficacy or side effects, as glutathione may influence liver metabolism and thus the pharmacokinetics of these drugs