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Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia

Diverticulitis is not listed as a known adverse effect in the Summary of Product Characteristics (SmPC) for Wegovy, nor has it been identified as a safety signal in post-marketing surveillance by the MHRA or EMA

doi: 10.1093/toxsci/kfm087 102 ZhangDLiuYZhangZLvPLiuYLiJet al

doi: 10.1158/1940-6207.CAPR-08-0173 229 GandinVKhalkarPBraudeJFernandesAP

Shaking creates foam and can damage the peptide bonds

Liraglutide (3 mg dose for weight loss) produces more modest weight loss and was one of the first GLP-1 drugs approved for obesity