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One unexpected serious adverse reaction occurred in a NAC-treated patient caused by an erroneous iv infusion rate (1.5g-loading dose-15 min followed by 7.5 g delivered over 3h15min instead of 4 h), causing chest tightness, despite stable vital signs, which was resolved by corticosteroids and discontinuation of iv NAC

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Although today several studies have investigated the mechanism involved in metabolic plasticity, but key pathway has not been identified which could be considered a unique target for cancer therapy

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