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Third, even if the GLP-1 increase is real, the downstream effects depend on duration, receptor binding affinity, and overall systemic exposure

Lancet Neurol 2012;11:697707.ArticlePubMed 45

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As for how the company ensures that the medication is getting to the right people, Phillips said their health-care providers review "the patients health history, current medications, contraindications, treatment goals and whether a GLP-1 is appropriate for them." "Lower cost may bring more people forward, but it does not change the clinical standard", she said

Vallis T, Macklin D, Russell-Mayhew S

Doctors usually start with a low dose to reduce side effects, so the strongest effects may not happen immediately