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At the enzymatic level, AOD 9604 has been shown to promote triglyceride hydrolysis while inhibiting lipogenesis through modulation of acetyl-CoA carboxylase activity

AntonelliAFerrariSMRagusaFEliaGPaparoSRRuffilliIet al

Mobile phase A was 10 mM ammonium acetate (pH 10, adjusted with ammonium hydroxide) in water and mobile phase B was prepared with 10% A / 90% ACN

Itching can also occur, but it is not common

The following day, assay media was prepared by supplementing specialized DMEM pH 7.4 (Agilent, 103575-100) with 10% dFBS, 1% penicillinstreptomycin, 25 mM glucose and 2 mM L-glutamine

However, after oral or systemic administration, Dex lacks organ-targeting capabilities, so higher doses and frequencies are required to achieve effective concentrations at the site of inflammation [103], which causes severe side effects on the hematological and alimentary systems [104]