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doi:10.1126/scitranslmed.3007218 16
doi: 10.33549/physiolres.934781 85 Maghsoumi-NorouzabadLZare JavidAMansooriADadfarMSerajianA
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A single dose of paracetamol of between 150200 mg/kg is sufficient to cause liver cell damage in adults
Taken together, mitophagy plays a dual role in iron-dependent cell death: under physiological states or the early stages of pathogenesis, including the development of oxidative stress, mitophagy degrades damaged mitochondria through negative feedback signaling, preventing ROS generation and hindering the initiation of iron-dependent cell death
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