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Additional evidence of systemic inflammation effecting the CNS is seen in a mouse model of intraperitoneal LPS injection, which revealed morphological changes in microglia after 3 h, suggestive of an activated state, that persisted up to one week post injection (Yang et al., 2013)

esculentus have also been reported to modulate the complex immune system

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J Clin Neurosci 2018;50:160162