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In obesity, hypertrophic expansion of adipocytes leads to hypoxia, oxidative stress, and the release of pro-inflammatory adipokines, thereby promoting insulin resistance and ectopic lipid deposition [31]

Our face has the largest network of lymphatic drainage

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The rarity of the lesion, which may present at different localizations create difficulty in placing a correct initial diagnosis

doi: 10.3389/fnagi.2021.776936 Received 14 September 2021 Accepted 30 November 2021 Published 23 December 2021 Volume 13 - 2021 Edited by Magorzata Kujawska, Pozna University of Medical Sciences, Poland Reviewed by Sandra Morais Cardoso, University of Coimbra, Portugal

10.2174/1389201019666180619145429 19 ChristiaensB.GrootenJ.ReusensM.JoliotA.GoethalsM.VandekerckhoveJ.et al (2004)