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As a multifactorial disorder, the pathogenesis of OA involves mechanical stress, genetic predispositions, metabolic dysregulation, and biomechanical imbalances [3]

Selenium and Glutathione Peroxidase Function Selenium serves as an essential cofactor for glutathione peroxidase, one of the primary enzymes that utilizes glutathione to neutralize hydrogen peroxide and lipid peroxides

4.1.2 Divalent metal ion transporter 1 (DMT1) DMT1 plays a crucial role in the transport of iron ions, and its abnormal expression in OA patients is closely associated with disease progression

Pre-treatment glutamine levels can independently predict survival of patients with CRC, with lower serum glutamine levels linked to poorer overall survival and lower progression-free survival (60)

Results In vitro ROS assay The antioxidant activity of NAC and NACET was assessed in an in vitro ROS assay in ARPE-19 cells using TBHP (200 M) as the oxidative stress-generating reagent