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As outlined above in DFUs, chronic hyperglycemia impairs innate immune responses and vascular function, leading to inefficient pathogen clearance and prolonged inflammation

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16 Biomarkers of oxidative stress have been reported in many neurological and psychiatric disorders, including Alzheimer's disease, 17 Parkinson's disease, 18 schizophrenia, 19, 20 bipolar disorder 21 and alcoholism, 22 and may reflect a common underlying pathophysiological mechanism

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It is commonly studied in models involving soft tissue response, gastrointestinal barrier integrity, inflammatory signaling, vascular response, and connective tissue remodeling