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The honest framing of the entire CagriSema record: strong, randomized, and consistent but measured against semaglutide, cagrilintide, and placebo, never against tirzepatide, and not yet backed by a regulatory approval

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Further supporting this concept, a two-sample Mendelian randomization study revealed a significant association between RA and inflammatory bowel disease (IBD) [65]

Clinical evidence for weight loss benefit is weak