, GRX1-roGFP2 or TRaQ-G) enable real-time, organelle-specific redox readouts but primarily report redox potential rather than absolute GSH levels, whereas fractionation coupled with mass spectrometry provides absolute GSH/GSSG quantification but remains static and susceptible to lysis-associated artifacts
The combined modifications produce a protein that retains full agonist activity at the type 1 IGF receptor (IGF-1R) while binding the IGF binding proteins (IGFBP-1 through IGFBP-6) with substantially reduced affinity
Anti-Cancer Agents Med
Dar HH, Anthonymuthu TS, Ponomareva LA, Souryavong AB, Shurin GV, Kapralov AO, et al
No personalized use recommendation outputs
Beyond the canonical GPX4-glutathione (GSH) axis, recent studies have identified additional protective mechanisms such as ferroptosis suppressor protein 1 (FSP1), guanosine triphosphate cyclohydrolase 1 (GCH1), and mitochondrial dihydroorotate dehydrogenase (DHODH), which provide complementary safeguards against ferroptotic death