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For instance, in Cogans syndrome the immunoglobulin G (IgG) immunoglobulins have an affinity for a supporting protein in the sensory epithelia of the inner ear Density-Enhanced Protein tyrosine phosphatase-1 (DEP-1/CD148) as well as connexin 26 that results in sensorineural hearing loss in mice [58]

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No notable adverse effects were observed during the 1-year follow-up