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For instance, a 10 mg/kg dose significantly reduced body weight by 11.2% and 7.4% in DIO mice and rats, respectively

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Research has highlighted the dual nature of BV, with compounds like melittin, and apamin exhibiting anti-inflammatory and pain-relieving properties, but also carrying the risk of irritation and allergic reactions in sensitized individuals (Jang and Kim, 2020

Thus, precise temporal and spatial modulation of TLR signaling is critical in wound infections to achieve an optimal balance between effective microbial clearance and controlled inflammation for successful tissue repair

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