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APAP has been widely used in pregnant women in the past decades because it is considered a relatively safe drug with recommended dose in different countries

SL drafted the manuscript

doi: 10.3389/fimmu.2018.00664 97 HarnettW

A small amount of water with food is fine, but large quantities can dilute digestive enzymes and stomach acid

Excessively consuming such diets not only directly affects energy metabolism in liver, but also increases the concentration of TMAO in plasma, which promotes the development of MAFLD by affecting bile acid metabolism, unfolded protein response, and oxidative stress