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An increase in plasma antioxidant capacity following the intake of polyphenol-rich foods, such as apples, tea, blackcurrants, and red wine, indicates that polyphenols can cross the intestinal barrier and exert systemic effects (113)

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Quercetin, another potent flavonoid, demonstrates dual modulation by both activating Nrf2 and inhibiting MAPK signaling cascades, thereby suppressing oxidative stressinduced neuronal apoptosis (Islam et al