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The muscle loss situation is that anytime you put somebody on a calorically restricted diet that's intensely calorically restricted, they're going to drop to 25 to 35, somewhere in there, percentage of lean mass loss that's on par with bariatric surgery, that's on par with very low-calorie diet

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This threshold was set given its importance from a clinical rather than a statistical viewpoint, and since it falls within the range normally accepted for this type of study [37]