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Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1

Newsome et al., 2021)

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GLP-1 RA therapies have also been noted to have heart and kidney protective effects, although benefits in the kidney at this time appear to be isolated to preventing the progression of proteinuria, and CV benefits appear to be primarily anti-atherosclerotic rather than on the basis of preventing HHF with SGLT2 inhibitors