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A subsequent study that followed 43 patients for up to four years found those with mild dementia or moderate-early dementia who took lipoic acid (600 mg/day), in addition to acetylcholinesterase inhibitors, experienced slower cognitive decline compared to the typical cognitive decline of Alzheimers patients as reported in the literature (102)

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Dihydrofolate reductase (DHFR) is a component that converts folate to dihydrofolate (DHF) and DHF to the active form, THF