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Synthetic lethality by targeting glutathione and pyrimidylate kinases in human CML-BC cell lines Finally, we further used several human blast-crisis CML cell lines, including K562, KOPM28, and TCCS, to verify the relationship between ATF4, GSH, and replication stress

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Implementing periodic washout phasessuch as 5 days on, 2 days off, or alternating weekspreserves receptor sensitivity while maintaining neuroplastic stimulus across extended protocols