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This is in contrast to most of other class A GPCRs, for which TM5 usually undergoes notable conformational changes at the cytoplasmic region during receptor activation 38

PubMed, Rice, Kevin M., et al

Diabetes 63 , 10791092 (2014)

The rodent Ccell findings often get cited, but in practice, clinicians reserve thyroid panels for targeted evaluation rather than blanket surveillance

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As demand for weight-loss treatments grows, pharmaceutical companies are racing to develop more efficient and accessible drugs