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Oral semaglutide (Rybelsus) must be taken on an empty stomach with up to 120ml of water, at least 30 minutes before food or other medications

Stimulant laxatives such as senna or bisacodyl should be reserved for occasional use rather than daily management

The advent of potent anti-inflammatory agents with their strong effects on reducing annualized relapsed rates has advanced the concept of progression independent of relapse activity (PIRA) (Lublin et al., 2022)