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Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus (as Mounjaro) and, more recently, for chronic weight management in adults with obesity or overweight with weight-related comorbidities (as Zepbound)

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[DOI] [PubMed] [Google Scholar] Mason HL, Myers CS, Kendall EC

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However, approximately 1% of any oral dose is absorbed passively through diffusion across the intestinal mucosa, regardless of intrinsic factor

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